CAR T-cell therapy is revolutionizing the treatment of hematological malignancy. Arnon Nagler, MD, Chaim Sheba Medical Center, Tel-Aviv, Israel, discusses CAR-T approaches to the treatment of acute lymphoblastic leukemia (ALL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma and multiple myeloma,. This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).