Farhad Ravandi, MD, University of Texas MD Anderson Cancer Center, Houston, TX, discusses the rationale and key findings of a study evaluating the safety and efficacy of ponatinib plus venetoclax in patients with relapsed/refractory (R/R) Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) (NCT03576547). This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.