John Gribben, MD, DSc, FRCP, FRCPath, FMed Sci, Barts Cancer Institute, London, UK, discusses patient risk stratification in chronic lymphocytic leukemia (CLL), drawing focus on the role of TP53 mutation, del(17p), and IgHV mutational status, and how these prognostic factors influence treatment approaches. This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.