Adam Sperling, MD, PhD, Dana-Farber Cancer Institute, Boston, MA, reflects on allogeneic and off-the-shelf CAR-T products in multiple myeloma, highlighting challenges associated with their use including higher doses of lymphodepleting therapy which increased toxicity, as well as reduced persistence resulting in decreased efficacy when compared to autologous products. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Annual Congress in Chicago, IL.
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