In this video, Marco Ruella, MD, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, shares some advice on what physicians should know regarding the use of chimeric antigen receptor T-cell (CAR-T) therapy when treating patients with chronic lymphocytic leukemia (CLL). Dr Ruella emphasizes the importance of ongoing clinical trials that are investigating the use of CAR-T products in CLL treatment, as CAR-T is not yet commercially approved for this malignancy. Dr Ruella then discusses how patients with high-risk disease or those who have relapsed should be considered for CAR-T trials, and how the management of toxicities related to CAR-T therapy have improved over the years. This interview took place during the 2nd ESH Translational Research Conference on Chronic Lymphocytic Leukemia (ESH CLL), 2022.