Ruben Mesa, MD, FACP, from the Mayo Cancer Clinic Center, Rochester, MN, USA, provides us an insight into the potential of treating patients with myeloproliferative neoplasms (MPN) with interferons. Here, he discusses the PROUD-PV study (NCT01949805), a Phase III trial comparing the efficacy and safety of the novel interferon AOP2014 against hydroxyurea in treating polycythemia vera, and notes that there may be selectivity in the interferon for clones of MPN. This interview was filmed at the European Hematology Association (EHA) 2017 Annual Congress in Madrid, Spain.