Valeria Santini, MD, University of Florence, Florence, Italy, provides an update on the use of lenalidomide for the treatment of myelodysplastic syndromes (MDS), highlighting the drugs’ importance in the management of del(5q) MDS. Prof. Santini goes on to discuss whether we should use lenalidomide in patients with del(5q) that are not transfusion-dependent. This interview took place at the 16th International Congress on Myelodysplastic Syndromes, held virtually in 2021.