Alexandre Hirayama, MD, Fred Hutchinson Cancer Research Center, Seattle, WA, discusses his recent research into the impact of response to lymphodepletion on PFS in non-Hodgkin lymphoma (NHL). This revealed that LDH, MCP-1, and IL-7 are independently associated with PFS in patients with aggressive NHL after CD19 CAR T-cell therapy. This interview took place at the 15th International Conference on Malignant Lymphoma (ICML), in Lugano, Switzerland.