Claire Harrison, MD, DM, FRCP, FRCPath, Guy’s and St Thomas’ NHS Foundation Trust, London, UK, shares some insights into the challenges of diagnosing and treating patients with myeloproliferative neoplasm-unclassifiable (MPN-U). Prof. Harrison also discusses some ongoing research being conducted in the UK evaluating this subset of MPN patients and future outlooks. This interview took place at the third annual Texas MPN Workshop (TMW) 2022, held in San Antonio, TX.