Jan Philipp Bewersdorf, MD, Memorial Sloan Kettering Cancer Center, New York City, NY, outlines the rationale for a Phase I study of ruxolitinib in combination with abemaciclib in patients with myelofibrosis (MF), explaining that pre-clinical data has shown synergistic activity between the CDK4/6 inhibitor abemaciclib and ruxolitinib. This combination may represent a promising option in patients who are resistant to ruxolitinib. This interview took place at the 64th ASH Annual Meeting and Exposition congress in New Orleans, LA.
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