Raajit Rampal, MD, PhD, Memorial Sloan Kettering Cancer Center, New York, NY, briefly comments on the use of venetoclax-based combinations in patients with accelerated and blast-phase myeloproliferative neoplasms (MPNs) and the need to further evaluate the best approach to using these combinations. This interview took place at the third annual Texas MPN Workshop (TMW) 2022, held in San Antonio, TX.