Gerardo Musuraca, MD, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy, discusses the changing treatment landscape of diffuse large B-cell lymphoma (DLBCL), and how this is guided by a greater molecular understanding of disease biology and pathogenesis. Dr Musuraca also highlights biological agents that have been developed for the different molecular subtypes of DLBCL. This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).