Gerardo Musuraca, MD, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy, outlines the Italian perspective of the diagnosis, treatment, and management of diffuse large B-cell lymphoma (DLBCL) including understanding molecular alterations involved in the pathogenesis of disease. This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).