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IMS 2024 | Investigating the use of mass spectrometry & NGF to measure MRD and predict outcomes in HR-SMM
Noemi Puig, MD, PhD, University Hospital Salamanca, Salamanca, Spain, discusses her recent study on the use of mass spectrometry (MS) in patients with high-risk smoldering myeloma (HR-SMM), focusing on its prognostic value compared to standard methods like serum protein electrophoresis and immunofixation. While standard methods lacked clinical value, MS and next-generation flow (NGF) identified groups with distinct prognoses, especially when tracking measurable residual disease (MRD) over time. Patients exhibiting persistent MRD-negativity showed favorable outcomes, while those remaining MRD-positive had poorer progression-free survival (PFS). This interview took place at the 21st International Myeloma Society (IMS) Annual Meeting, held in Rio de Janeiro, Brazil.
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