Mohamad Mohty, MD, PhD, Saint-Antoine Hospital, Paris, France, highlights some of the challenges faced by clinicians when treating older, transplant-ineligible patients with multiple myeloma. Dr Mohty mentions some of the issues in this area, including managing these patients and accurately assessing frailty, which will all be discussed by specialists at the 8th World Congress on Controversies in Multiple Myeloma (COMy), 2022.