Josep-Maria Ribera, MD, PhD, Germans Trias i Pujol University Hospital, Barcelona, Spain, highlights the importance of genetic screening in acute lymphoblastic leukemia (ALL) by conventional cytogenetics, fluorescence in situ hybridization (FISH), and reverse transcription polymerase chain reaction (RT-PCR) methods. This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).