Talha Munir, MBBS, Leeds Teaching Hospitals NHS Trust, Leeds, UK discusses the role of minimal residual disease (MRD) in the new era of targeted drugs. Munir refers to three trials: MURANO, CLL14 and CLARITY (ISCRTN13751862, NCT02005471, NCT02242942), with regards to how measurable residual disease (MRD) is being used to personalize treatment and predict response. This interview took place at the 18th International Workshop on Chronic Lymphocytic Leukemia (iwCLL) Biennial Meeting, held in Edinburgh, UK.