Deepti Radia, MBBS, BSc, MRCPI, FRCPath, MSc Med Ed, Guy’s and St Thomas’ NHS Foundation Trust, London, UK, shares some insights into the safety and efficacy of avapritinib in patients with advanced systemic mastocytosis, and further highlights results from the PATHFINDER (NCT03580655) and EXPLORER (NCT02561988) trials. This interview took place at the third annual Texas MPN Workshop (TMW) 2022, held in San Antonio, TX.