Kwee Yong, PhD, FRCP, FRCPath, University College London, London, UK, discusses the biological and psychological uncertainties in precursor disease, focusing on smoldering multiple myeloma (SMM). Prof. Yong highlights the complexities of the genomic and immunological changes in patients, noting the need for dynamic risk models to better predict disease progression. Psychological uncertainty is also significant, as patients are unsure about when or if they will progress to multiple myeloma, along with uncertainties regarding treatment outcomes, toxicities, and access to optimal future care. This interview took place at the 21st International Myeloma Society (IMS) Annual Meeting, held in Rio de Janeiro, Brazil.
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