Ola Landgren, MD, PhD, of the Memorial Sloan Kettering Cancer Center, NY, discusses new quadruplet regimens for newly diagnosed multiple myeloma (MM), specifically daratumumab, carfilzomib, lenalidomide and dexamethasone (DKRd). Dr Landgren also covers the bone marrow-based and longitudinal blood-based MRD tracking of this group. This interview took place at the American Society of Hematology (ASH) 2018 Annual Meeting and Exposition in San Diego, CA.