Sara Ghorashian, PhD, MD, FRCP, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK, shares some insights into the management of relapse after CAR-T therapy in patients with acute lymphoblastic leukemia (ALL). Dr Ghorashian emphasizes the importance of thorough and systematic data collection and how this data can be used to improve approaches after relapse. This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.