Ruben Mesa, MD, UT Health San Antonio MD Anderson Cancer Center, San Antonio, TX, gives an overview of upcoming agents in polycythemia vera (PV) and essential thrombocythemia (ET), including ropeginterferon alfa-2b, bomedemstat, and rusfertide, and clinical trials investigating these agents. This interview took place at the third annual Texas MPN Workshop (TMW) 2022, held in San Antonio, TX.