ASH 2022 | A Phase I study investigating ruxolitinib and abemaciclib for primary or secondary myelofibrosis
Prithviraj Bose, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, describes an ongoing Phase I study which is investigating the novel combination of ruxolitinib and abemaciclib for patients with myeloproliferative neoplasms (MPNs). Dr Bose believes that the combination of a JAK-1/2 and CDK4/6 inhibitor could have synergistic effects in patients with primary or secondary myelofibrosis (MF) who have an inadequate response to ruxolitinib monotherapy. The primary endpoint of this study is to determine the safety and tolerability of this novel combination, and encouraging results are expected. This interview took place at the 64th ASH Annual Meeting and Exposition congress in New Orleans, LA.
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Disclosures
NS Pharma: Research Funding; Morphosys: Honoraria, Research Funding; Kartos: Honoraria, Research Funding; Sierra Oncology: Honoraria; Karyopharm: Honoraria; Ionis: Research Funding; Incyte: Honoraria, Research Funding; CTI BioPharma: Honoraria, Research Funding; PharmaEssentia: Honoraria; Cogent: Honoraria, Research Funding; Blueprint: Honoraria, Research Funding; BMS: Honoraria, Research Funding; AbbVie: Honoraria; Promedior: Research Funding.
