In this video, Joshua Richter, MD, Tisch Cancer Institute at Mount Sinai, New York, NY, discusses the management of patients with difficult to treat multiple myeloma, highlighting the importance of understanding functionally high-risk disease and evaluating additional genomic information in these patients. Dr Richter also comments on important novel agents to consider, such as belantamab mafodotin and selinexor. This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.