Roei Mazor, MD, PhD, Assuta Medical Center, Tel Aviv, Israel, shares some insights into the treatment of Langerhans cell histiocytosis. Dr Mazor first provides some background on the biology of this rare disease, and then goes on to explain how treatment approaches for Langerhans cell histiocytosis have improved due to a better understanding of driver mutations. This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.