Roei Mazor, MD, PhD, Assuta Medical Center, Tel Aviv, Israel, discusses a case study in which a patient with PI3K-driven Langerhans cell histiocytosis was treated with alpelisib. Dr Mazor first highlights driver mutations commonly found in this rare disease and then discusses the impressive results observed with the use of alpelisib. This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.