Florence Cymbalista, MD, PhD, Avicenne Hospital, Bobigny, France, discusses the prognostic value of high-sensitivity MRD assessment after front-line chemoimmunotherapy in chronic lymphocytic leukemia (CLL). Based on investigations from FILO group trial findings, high-sensitivity MRD in blood yielded additional prognostic information beyond the current standard sensitivity (0.01%). This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).