In this video, Sigurdur Kristinsson, MD, PhD, University of Iceland, Reykjavík, Iceland, briefly discusses advances in screening capabilities for precursor conditions, highlighting the use of protein electrophoresis, immunofixation, and more recently, mass spectrometry. This interview took place at the 8th World Congress on Controversies in Multiple Myeloma (COMy) 2022, held in Paris, France.