Saad Usmani, MD, MBBS, MBA, Levine Cancer Institute and Atrium Health, Charlotte, NC, gives an update on the CARTITUDE-1 trial (NCT03548207) of ciltacabtagene autoleucel (cilta-cel) in patients with relapsed/refractory multiple myeloma, highlighting health-related quality of life (QoL) data. 95% of patients receiving cilta-cel experienced cytokine release syndrome (CRS) with 4% grade three of four, and neurotoxicity was observed in 20.6% of patients, with grade three of four in 9%. At a median follow-up of 12.4 months, the progression-free survival rate was 76.6% and overall survival rate was 88.5%. This interview took place during the 47th Annual Meeting of the European Group for Blood and Marrow Transplantation (EBMT) 2021.