Arnon Nagler, MD, Chaim Sheba Medical Center, Tel-Aviv, Israel, presents the key talking points in CAR T-cell therapy for the treatment of multiple myeloma. Prof. Nagler discusses how CAR-T therapy is achieving unprecedented results for advanced myeloma, with the additional benefit of low toxicity. Questions remain in the field, with research ongoing into optimization strategies and addressing resistance development to common CAR-T targets. This interview took place during the 7th World Congress on Controversies in Multiple Myeloma (COMy), 2021.