Toby Eyre, MBChB (Hons), DipMedEd, MRCP (UK), FRCPath (UK), MD, Oxford University Hospitals NHS Foundation Trust, Oxford, UK, discusses novel agents in chronic lymphocytic leukemia (CLL) and ibrutinib’s place in the CLL treatment landscape, highlighting the importance of combination approaches. Dr Eyre also comments on the future role of CAR-T cell therapy in CLL and how ibrutinib’s role may change in the years to come. This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.