BSH 2024 | Approaching treatment selection and sequencing with the recent influx of BTK inhibitors in CLL
Dima El-Sharkawi, MBBS, MA, PhD, MRCP, FRCPath, The Royal Marsden NHS Foundation Trust, London, UK, shares insight into the best way to sequence currently available BTK inhibitors (BTKi) when treating patients with chronic lymphocytic leukemia (CLL). In patients who lose response to a first- or second-generation BTKi (ibrutinib, acalabrutinib, or zanubrutinib), the reversible BTKi pirtobrutinib can be used. Following this, other approaches for targeting BTK, such as using BTK degraders, may show promise for patients who fail on pirtobrutinib. This interview took place at the 64th Annual Scientific Meeting of the British Society for Haematology (BSH) Congress in Liverpool, UK.
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Disclosures
Honoraria: Abbvie; AstraZeneca; Beigene; Gilead, Janssen; Lily; Roche; Takeda
Conference/ Travel support: Abbvie; Novartis; Roche
Ad boards: Abbvie; ASTEX; AstraZeneca; Beigene; Janssen; Kyowa Kiirin
