Toby Eyre, MBChB (Hons), DipMedEd, MRCP (UK), FRCPath (UK), MD, Oxford University Hospitals NHS Foundation Trust, Oxford, UK, shares some insights into BRUIN CLL-322, a Phase III open-label, randomized study evaluating the use of pirtobrutinib plus venetoclax and rituximab versus venetoclax and rituximab in relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL). This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.