ASH 2023 | Real-world efficacy & safety of teclistamab in patients with BCMA-pretreated R/R multiple myeloma
Rachid Baz, MD, Moffitt Cancer Center, Tampa, FL, discusses a single institution study addressing the real-world safety and efficacy of teclistamab in patients with BCMA-pretreated relapsed/refractory (R/R) multiple myeloma (MM). Teclistamab was approved based on the MajesTEC-1 trial (NCT04557098); however, many patients in the clinic present with a range of high-risk features, making them ineligible for this trial. Dr Baz indicates that the efficacy of teclistamab was relatively well maintained in the real-world population when comparing the progression-free survival (PFS) and toxicity to MajesTEC-1 data; however, response rates were slightly lower. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.
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Disclosures
Research Funding: Regeneron, Pfizer, Karyopharm, Janssen, AbbVie, BMS; Honoraria: GSK, HIKMA Cancer Network, Curio Science, AHOMPR, ASH; Membership on an entity’s Board of Directors or advisory committees: Pfizer, Janssen, BMS.
