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COSTEM 2022 | Do CAR-T therapies play a role in earlier lines of therapy in multiple myeloma?

Pieter Sonneveld, MD, PhD, Erasmus University, Rotterdam, The Netherlands, comments on current research assessing CAR-T therapy in earlier settings in multiple myeloma, where they are currently indicated for relapsed or heavily pretreated patients. The Phase III KarMMa-3 trial (NCT03651128) and the Phase II CARTITUDE-2 trial (NCT04133636) have demonstrated the potential of moving CAR-T therapies into earlier lines of therapy. Dr Sonneveld also highlights additional trials investigating CAR-Ts with maintenance bispecific antibodies in multiple myeloma. This interview took place at the 7th Congress on Controversies in Stem Cell Transplantation and Cellular Therapies (COSTEM) in Berlin, Germany.

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Research funding from Amgen, Celgene, Janssen, Karyopharm, SkylineDx, Takeda; Advisory Board: Amgen, BMS, Celgene, Janssen, Karyopharm, Takeda.

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