Prithviraj Bose, MD, The University of Texas MD Anderson Cancer, Houston, TX, talks on updates from the Phase I/II MANIFEST (NCT02158858) trial on pelabresib with and without ruxolitinib for patients with myelofibrosis. Dr Bose shares updated data on the improvements in spleen size, anemia and symptoms. This interview took place during the ninth annual meeting of the Society of Hematologic Oncology (SOHO 2021) congress.