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EORTC CLTF 2021 | The effect of CXCR4 inhibition on malignant cells

Lilach Moyal, PhD, Tel Aviv University, Tel Aviv, Israel, talks on CXCR4 and its potential role as a therapeutic target in mycosis fungoides (MF). CXCR4 is a G-protein coupled chemokine receptor playing a role in cell survival that is overexpressed in many solid and liquid tumors, including MF. Experiments showed that inhibition of this receptor led to inactivation of the MAPK and PI3K downstream signaling cascades involved in chemotaxis, apoptosis and survival, thus highlighting the potential of using a CXCR4 inhibitor in the context of MF. This interview took place at the EORTC Cutaneous Lymphoma Group 20-21 meeting in Marseille.

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