Paola Neri, MD, PhD, University of Calgary, Calgary, AB, Canada, discusses the promise of novel CAR-T therapy strategies for the treatment of multiple myeloma. Several approaches are under investigation that may improve efficacy and response durability. These include the use of allogenic CAR-T products, dual targeting, and optimized manufacturing. CAR T-cell therapy and immunotherapy remain in the spotlight as new exciting findings continue to emerge. This interview took place during the 7th World Congress on Controversies in Multiple Myeloma (COMy), 2021.