Deciding the correct sequencing of treatment for chronic lymphocytic leukemia (CLL) patients is an important step. Florence Cymbalista, MD, PhD from Avicenne Hospital, Bobigny, France talks us through some examples of how the order of treatments, such as BCR inhibitors and chemotherapy, are carefully considered to ensure the best possible outcome for the patient. Dr Cymbalista also discusses how these considerations will affect the aim of future clinical trials. This interview was recorded at the 2017 European Hematology Association (EHA) annual congress held in Madrid, Spain.