Michelle Kenyon, King’s College Hospital NHS Foundation Trust, London, UK, discusses the need for managing expectations not only for patients and their families but also for HCPs. Ms Kenyon highlights the significant information about this groundbreaking treatment and HCPs’ responsibility to make that information relevant and understandable for patients. It is also important for HCPs to be able to prepare patients for the potential consequences of CAR T-cell therapy. This interview took place at the 2nd European CAR T-Cell Meeting in Sitges, Spain.