Marina Konopleva, MD, PhD, of The University of Texas MD Anderson Cancer Center, Houston, TX, outlines clinical updates evaluating the use of agents targeting apoptotic signals in acute myeloid leukemia (AML), including venetoclax, a BCL-2 inhibitor, in combination with azacitidine, as well as triplet combinations with FLT3 inhibitors or novel monoclonal antibodies. This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).