Valeria Santini, MD, University of Florence, Florence, Italy, discusses the therapy options for transfusion-dependent, low-risk myelodysplastic syndromes (MDS) patients. Specifically, the stimulation of erythropoiesis with the TGF-β targetting galunisertib and the ligand-trapping luspatercept and sotatercept is outlined. This interview was recorded during an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).