Lanny Kirsch, MD, Senior Vice President in Translational Medicine at Adaptive Biotechnologies, Seattle, WA, discusses the work conducted by a group formed to analyse the use of measurable residual disease (MRD) in the treatment of multiple myeloma. Dr Kirsch summarizes the key points from a paper put together by a consortium of academic, industry and government foundations which provided the background into the current status of MRD, regulatory considerations and the technologies involved. Dr Kirsch explains the valuable insights gained with the use of MRD, such as clinical status, response to therapy and tumour burden, and talks on the need for a highly accurate, sensitive, and standardized approach to measure outcomes. This interview took place during the 18th International Myeloma Workshop (IMW 2021) congress.