Roberto Mina, MD, University of Turin, Turin, Italy, comments on T-cell exhaustion, which limits the efficacy of CAR-T therapy in triple-class exposed patients with multiple myeloma. He highlights the lack of data but suggests using bispecific antibodies instead, as there is good data on the effectiveness of these agents. This discussion took place at the 1st International Workshop on High-Risk Multiple Myeloma (iwHRMM 2024), held in Charleston, SC.
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