In this video, Sagar Lonial, MD, FACP, Winship Cancer Institute of Emory University, Atlanta, GA, briefly discusses the debate around using measurable residual disease (MRD) to guide treatment in multiple myeloma and the importance of upcoming clinical trials in answering questions in this field. This interview took place at the 8th World Congress on Controversies in Multiple Myeloma (COMy) 2022, held in Paris, France.