ASH 2022 | A Phase I/II study evaluating MS-553 in patients with CLL/SLL
James Blachly, MD, The Ohio State University, Columbus, OH, discusses the trial design of a study which is investigating the efficacy of MS-553, a protein kinase C (PKC) β inhibitor, in refractory patients with chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) (NCT03492125). Dr Blachly highlights that the study consists of three cohorts: MS-553 monotherapy, MS-553 in combination with acalabrutinib, and MS-553 with venetoclax plus an anti-CD20 antibody. This interview took place at the 64th ASH Annual Meeting and Exposition congress in New Orleans, LA.
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Disclosures
MingSight Pharmaceuticals: Research Funding; AstraZeneca: Consultancy, Membership on an entity’s Board of Directors or advisory committees; INNATE Pharma: Consultancy, Membership on an entity’s Board of Directors or advisory committees; KITE Pharma: Consultancy, Membership on an entity’s Board of Directors or advisory committees; Astellas: Consultancy, Membership on an entity’s Board of Directors or advisory committees; AbbVie: Consultancy, Membership on an entity’s Board of Directors or advisory committees.
