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COSTEM 2022 | The utility of CD34-selected peripheral blood stem cell graft as GvHD prevention in HLA allografts

Miguel-Angel Perales, MD, Memorial Sloan Kettering Cancer Center, New York, NY, discusses the role of T cell selection in ablative matched unrelated donor (MUD) transplants. Despite CD34 selection being inferior to post-transplant cyclophosphamide and tacrolimus as graft-versus-host disease (GVHD) prophylaxis in the PROGRESS II trial (NCT02345850), CD34 selection is still a promising strategy. Reducing cytomegalovirus (CMV) infection as well as administering anti-thymocyte globulin (ATG) based on lymphocyte count pre-conditioning therapy will additionally enhance CD34 selection in patients. This interview took place at the 7th Congress on Controversies in Stem Cell Transplantation and Cellular Therapies (COSTEM) in Berlin, Germany.

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