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COSTEM 2022 | The impact of CAR-T therapy in the second-line setting in lymphoma

Miguel-Angel Perales, MD, Memorial Sloan Kettering Cancer Center, New York, NY, describes the effect of introducing CAR-T therapies such as axicabtagene ciloleucel (axi-cel) and lisocabtagene maraleucel (liso-cel) as second-line therapies in lymphomas such as diffuse large B-cell lymphoma (DLBCL). Despite negative results from the BELINDA trial (NCT03570892), the ZUMA-7 (NCT03391466) and TRANSFORM trials (NCT03575351) have enabled the approval of CAR-Ts into the armamentarium. This interview took place at the 7th Congress on Controversies in Stem Cell Transplantation and Cellular Therapies (COSTEM) in Berlin, Germany.

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