Jose Villasboas, MD, Mayo Clinic, Rochester, Minnesota, MN, discusses the rationale and design of the ongoing Phase II Dual Immunomodulation in Aggressive Lymphoma (DIAL) trial (NCT03038672). This trial investigates varilumab plus nivolumab in aggressive B-cell lymphomas. This interview took place at the 15th International Conference on Malignant Lymphoma (ICML), in Lugano, Switzerland.