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ERIC 2026 | Essential genomic tests and patient-centered treatment decisions in CLL

Mary Ann Anderson, MBBS, FRACP, FRCPA, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia, discusses the role of TP53, del(17p), IGHV mutation status, and karyotypic complexity in guiding first-line treatment decisions for chronic lymphocytic leukemia (CLL). Dr Anderson highlights the practical challenges of accessing molecular testing and emphasizes the importance of patient preferences, comorbidities, and treatment duration when choosing between continuous BTK inhibition and fixed-duration venetoclax-based therapy. This interview took place at the 2026 ERIC International Meeting in Barcelona, Spain.

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